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Do You Need a Liver Function Test (LFT)? Key Signs to Watch For

PBTT

Private Blood Tests Team

Clinical Team

29 Dec 202510 min read

Do you feel a bit off recently? Maybe you are more fatigued than normal, or your digestion has been acting up. Perhaps you have noticed changes in your skin or eyes, or you simply have a nagging feeling that something is not quite right. These subtle signs could be your body telling you that your liver needs attention.

The liver is one of your body's most vital organs, quietly performing hundreds of essential functions every day. Yet because liver problems often develop silently, many people are unaware their liver is struggling until significant damage has occurred. A liver function test (LFT) can provide crucial insights into your liver health, potentially catching problems early when they are most treatable.

What Is a Liver Function Test?

A liver function test is a blood test that measures various enzymes, proteins, and substances produced or processed by the liver. Despite the name, these tests do not just assess how well your liver is functioning — they can also detect liver damage, inflammation, and certain diseases.

A standard LFT typically includes:

  • ALT (Alanine Aminotransferase) — An enzyme primarily found in liver cells. Elevated levels indicate liver cell damage.
  • AST (Aspartate Aminotransferase) — Found in the liver and other organs. Elevated with liver damage but less specific than ALT.
  • ALP (Alkaline Phosphatase) — Elevated levels may indicate bile duct problems or bone disease.
  • GGT (Gamma-Glutamyl Transferase) — Sensitive to alcohol consumption and bile duct issues.
  • Bilirubin — A yellow pigment produced when red blood cells break down. Elevated levels cause jaundice.
  • Albumin — A protein made by the liver. Low levels suggest the liver is not functioning properly.
  • Total Protein — Measures albumin and globulins combined.
  • For a comprehensive explanation of what each marker means, read our detailed guide to decoding your liver function tests.

    Key Signs You May Need a Liver Function Test

    ### 1. Unexplained Fatigue

    Persistent tiredness that does not improve with rest is one of the most common early signs of liver problems. When the liver is struggling, toxins that would normally be filtered out can accumulate in the bloodstream, causing fatigue and a general feeling of being unwell.

    If you are experiencing unexplained tiredness, it is worth investigating. Read our article on why you should not ignore tiredness to learn more about what fatigue could be telling you.

    ### 2. Digestive Problems

    The liver produces bile, which is essential for digesting fats. When liver function is impaired, you may experience:

  • Nausea, particularly after fatty meals
  • Loss of appetite
  • Bloating and discomfort
  • Changes in bowel habits
  • Pale or clay-coloured stools
  • ### 3. Abdominal Discomfort

    Pain or discomfort in the upper right area of your abdomen, where the liver is located, can indicate liver inflammation or enlargement. This may feel like a dull ache or a sense of fullness.

    ### 4. Skin and Eye Changes

    The liver processes bilirubin, a yellow pigment. When the liver cannot process bilirubin properly, it accumulates, causing:

  • Jaundice — Yellowing of the skin and whites of the eyes
  • Itchy skin — Bile salts depositing in the skin
  • Easy bruising — Reduced production of clotting factors
  • Spider angiomas — Small, spider-like blood vessels visible on the skin
  • For more information about bilirubin and what elevated levels mean, read our guide to understanding bilirubin tests.

    ### 5. Dark Urine

    When bilirubin levels rise, excess bilirubin is excreted through the kidneys, causing urine to become dark brown or tea-coloured. This is often one of the first noticeable signs of liver problems.

    ### 6. Swelling

    Advanced liver disease can cause:

  • Ascites — Fluid accumulation in the abdomen
  • Oedema — Swelling in the legs and ankles
  • These occur when the liver cannot produce enough albumin, leading to fluid leaking out of blood vessels.

    ### 7. Unexplained Weight Changes

    Both weight loss (due to loss of appetite and muscle wasting) and weight gain (due to fluid retention) can occur with liver problems.

    Risk Factors That Warrant Testing

    Even without symptoms, you should consider a liver function test if you have risk factors for liver disease:

    Lifestyle factors:

  • Regular alcohol consumption
  • Overweight or obesity
  • Poor diet high in processed foods and sugar
  • Sedentary lifestyle
  • Medical factors:

  • Type 2 diabetes or prediabetes
  • High cholesterol
  • History of viral hepatitis exposure
  • Family history of liver disease
  • Taking medications that can affect the liver
  • Autoimmune conditions
  • Occupational factors:

  • Exposure to toxic chemicals
  • Healthcare workers (hepatitis risk)
  • Common Liver Conditions LFTs Can Detect

    ### Non-Alcoholic Fatty Liver Disease (NAFLD)

    NAFLD is the most common liver condition in the UK, affecting up to 30% of the population. Fat accumulates in the liver, potentially causing inflammation and damage. It is strongly associated with obesity, diabetes, and metabolic syndrome.

    ### Alcoholic Liver Disease

    Excessive alcohol consumption damages the liver progressively, from fatty liver to alcoholic hepatitis to cirrhosis. LFTs, particularly GGT, are sensitive indicators of alcohol-related liver damage.

    ### Viral Hepatitis

    Hepatitis B and C can cause chronic liver inflammation and, if untreated, cirrhosis and liver cancer. LFTs help monitor liver damage, though specific viral tests are needed for diagnosis.

    ### Drug-Induced Liver Injury

    Many medications can affect the liver. Regular LFTs are important if you take medications known to have hepatotoxic potential.

    For comprehensive information about liver health and what blood tests reveal, read our article on liver health matters.

    What Happens During the Test?

    A liver function test is a simple blood test:

  • A small sample of blood is taken from a vein in your arm
  • The procedure takes only a few minutes
  • Results are typically available within 24-48 hours
  • Fasting is not always required, but check with your provider
  • For general information about the blood testing procedure, read our comprehensive overview of blood testing.

    Interpreting Your Results

    LFT results should always be interpreted by a healthcare professional, as:

  • Minor elevations may not be significant
  • Patterns across multiple markers provide more information than single values
  • Results must be considered in context of symptoms and medical history
  • Some medications and conditions can affect results
  • When to Act

    Do not wait for obvious symptoms to appear. The liver has remarkable regenerative capacity, meaning it can be significantly damaged before symptoms develop. Early detection through blood testing allows for intervention when treatment is most effective.

    If you have risk factors or any concerning symptoms, a liver function test provides valuable peace of mind or early warning.

    Liver Function Testing in London

    At Private Blood Tests London, we offer comprehensive liver function panels at our CQC-registered clinic in South Kensington. Our tests provide detailed insights into your liver health, with results typically available within 24-48 hours.

    For a complete understanding of your liver markers, read our detailed guide to [decoding your liver function tests](/blog/decoding-your-liver-function-tests-lfts) and explore our [liver function test page](/liver-function-test).

    Your liver works hard for you every day. Find out how it is doing. Book your liver function test today.

    Ready to Book Your Test?

    Visit our CQC-registered clinic in South Kensington for professional blood testing services.